There is nothing more fulfilling for us, as fertility specialists, than making sure every couple that comes to the clinic achieves a healthy live birth, regardless of their fertility history or the fact that they may have experienced repeated failures in the past. For that reason, Team Miracle keep their eyes locked on the latest advances in reproductive medicine and the field of reproduction in general. For us, no case is a desperate case of infertility that we cannot help. As part of our constantly updated services, we are proud to present you with EmbryoGen and BlastGen.

But first, let’s see what problem EmbryoGen and BlastGen have come to help counteract.

Why Do Some Couples Suffer Unexplained Infertility & Pregnancy Loss ?

It’s been evidenced that about 40% of couples with unexplained infertility and an overwhelming 80% of pregnancy losses may be due to a failed communication between the embryo and the mother.

From the moment of fertilitsation and onwards, the fertilised embryo and the mother communicate actively so that the mother’s body recognises and accepts the tiny foreign organism. The result of this “dialogue” can either allow the embryo to be implanted in the mother’s uterus, where it will remain throughout pregnancy (establishing a successful pregnancy), or be rejected.

Valuable helpers in this communication are cytokines – important regulators of the embryo-uterus communication before the implantation occurs. Reduced cytokine levels elevate the risk of miscarriage due to implantation failure. So, if the mother does not produce enough GM-CSF cytokines* (for reasons we still have not identified completely), her body might reject the embryo right after implantation. That woman is likely to experience an early miscarriage and recurrent failed IVF attempts. When a pregnancy loss is the outcome of a mother-embryo communication error, steroid-based medication cannot guarantee a pregnancy, unlike with other cases. We need to restore communication before we do anything else.

*A cytokine all women naturally have in their reproductive system. After the intercourse, GM-CSF is expressed into the lumen and uterus and remains high for some days after conception. When the implantation occurs, additional GM-CSF is produced to help regulate the embryo, endometrium, and placenta, among others.

Introducing EmbryoGen – A Novel Treatment Option

EmbryoGen is a highly advanced embryo culture medium that contains the GM-CSF growth factor cytokine. Cytokines create an environment in the embryos that are in-vitro cultivated which improves their development and allows them to sink into the endometrium (implant) and continue to grow there.

Embryos are cultured until the 2-8 cell stage development during the IVF process and are returned to the mother’s uterus on day 2 or 3, along with a small amount of EmbryoGen so the “dialogue” between the uterus and the embryo can lead to the desired outcome.
Important Note: EmbryoGen was tested in more than 1300 IVF patients (one of the largest IVF trials in the world) and showed significant improvement in women that have suffered one or multiple miscarriages in the past.

Introducing BlastGen – The Next Phase

With BlastGen treatment, we culture the embryo in an environment that mimics what happens in a mother during conception, which allows the embryo to grow in a more natural environment than with traditional IVF treatments. As with EmbryoGen, BlastGen also contains GM-CSF cytokine, the signaling molecule found naturally in a mother’s uterus that makes the embryo more robust and stronger in the days after conception while also protecting it from stress. It should be noted that BlastGen is the only advanced IVF medium that contains that molecule.

Overall, both EmbryoGen and BlastGen help provide a more natural in vitro environment and improve the embryo-mother communication, offering a non-invasive, low-cost alternative compared to the more expensive (and harsher) treatments for miscarriages or failed cycles.

Are You a Good Candidate for EmbryoGen & BlastGen ?

Patients undergoing their IVF at the Cyprus IVF Clinic are all eligible to use both EmbryoGen and BlastGen, regardless of the type of treatment they are receiving here. However, EmbryoGen is specifically recommended for patients that have experienced:

  • Repeated Pregnancy Loss – According to studies, women that have suffered unexplained recurrent miscarriage(s) (either biochemical or clinical) had significantly reduced GM-CSF levels.
  • Repeated Implantation Failure – Research and studies have shown that GM-CSF boosts clinical pregnancy rates in patients with recurrent implantation failure.
  • Unexplained Infertility – It’s been evidenced that women suffering unexplained infertility had significantly low GM-CSF levels in follicular fluid (a liquid that provides a critical micro-environment for oocyte (egg) development).

EmbryoGen can also be used for women with poor quality eggs or older women than want to use their own eggs rather than donor eggs and undergo an IVF treatment. For these women, Dr. Firdevs is more likely to do a Day 3 embryo transfer to increase their pregnancy rates.

BlastGen, on the other hand, can be used for couples:

  • Struggling with male factor infertility.
  • That want to have PGD ( Pre-Implantation Genetic Diagnosis ) treatment – For gender selection and to improve the quality of the embryo before and after the embryo biopsy.
  • With a history of failed implantation and failed cycles* – At the Cyprus IVF Clinic, we see many patients that have tried other options, such as such as hysteroscopy and immune treatment, and have not managed to experience a successful IVF cycle. To help the IVF process in these cases, we strongly recommend the use of BlastGen and EmbryoGen.
  • That have experienced miscarriages in the past.*
    * As long as the embryos had no issues when developing to blastocyst stage.


The Process

The Team Miracle embryologist will perform Intra-cytoplasmic sperm injection (ICSI) fertilisation (inject a single sperm directly into an egg). As soon as it’s completed, the oocytes will be transferred into wells of pre-equilibrated BlastGen or EmbryoGen and then return to our state-of-the-art benchtop incubators. However, you may also ask to have them returned to our EmbryoScope time-lapse incubator – a stellar device that allows us to monitor 24/7 the development of the fertilised eggs without exposing them to environmental changes (we don’t remove embryos from the incubator).

The 2-to-5-day period an embryo spends outside the mother’s body is very sensitive because the embryo relies on its environment to grow. So, the embryologist at the Cyprus IVF Clinic is called to make sure the developing embryos receive optimal care and are provided with the best possible environment. The culture medium (fluid) in which they are kept is the principle influencing factor and could not only mimic the natural environment of the embryo but also provide it with the essential nutrients to develop.

The culture media are constantly advancing so that they can imitate the mother as much as possible. Undeniably, the better the media, the more chances the embryo has to implant and the pregnancy leads to a successful live birth.

One of the reasons our patients have decided to try IVF abroad and come to the Cyprus IVF clinic is because of our worldwide spread reputation as fertility specialists with the highest success rates on the island and three times the success rates of UK-based fertility centres. Instead of using conventional IVF media, we have chosen to stay focused on the future of IVF and the latest advances in the field.

It’s not by accident that we are the ONLY fertility team in Cyprus offering EmbryoGen and BlastGen both of which have been proven to provide much-valuable support to even the most challenging cases we have been called to treat.

NO case is untreatable for Team Miracle.

So, don’t hesitate to contact us and discuss your fertility problems or learn more about the wondrous EmbryoGen and BlastGen media.